| Etapa 1 |
| 14/04/2022/ 18:15/ Cricova – APSM | 0:5 |
14/04/2022/ 20:30/ CS Olimp-Veteran Cahul – FC Chișinău
| 4:2 |
14/04/2022/ 21:30/ Dnestr Tiraspol – ARF Ialoveni
| 2:0 |
14/04/2022/ Geotermal Chișinău – liberă
| |
| Etapa 2 |
21/04/2022/ 18:30/ FC Chișinău – Cricova
| 7:3 |
21/04/2022/ 19:30/ APSM – Dnestr Tiraspol
| 1:4 |
| 21/04/2022/ 20:30/ Geotermal Chișinău – CS Olimp-Veteran Cahul | 6:3 |
21/04/2022/ ARF Ialoveni – liberă
| |
| Etapa 3 |
28/04/2022/ 18:30/ Cricova – Geotermal Chișinău
| 2:6 |
28/04/2022/ 19:30/ ARF Ialoveni – APSM
| 3:2 |
28/04/2022/ 20:30/ Dnestr – FC Chișinău
| 5:3 |
28/04/2022/ CS Olimp-Veteran Cahul – liberă
| |
| Etapa 4 |
05/05/2022/ 18:30/ FC Chișinău – ARF Ialoveni
| 7:1 |
05/05/2022/ 19:30/ Geotermal Chișinău – Dnestr Tiraspol
| 6:3 |
05/05/2022/ 20:30/ CS Olimp-Veteran Cahul – Cricova
| 3:1 |
05/05/2022/ APSM – liberă
| |
| Etapa 5 |
12/05/2022/ 18:15/ APSM – FC Chișinău
| 2:2 (1:2 bulit) |
12/05/2022/ 20:30/ Dnestr Tiraspol – CS Olimp-Veteran Cahul
| 3:3 (1:0 bulit) |
12/05/2022/ 21:30/ ARF Ialoveni – Geotermal Chișinău
| 2:5 |
12/05/2022/ Cricova – liberă
| |
| Etapa 6 |
19/05/2022/ 18:30/ Geotermal Chișinău – APSM
| 2:3 |
19/05/2022/ 19:30/ Cricova – Dnestr Tiraspol
| 0:9 |
19/05/2022/ 20:30/ CS Olimp-Veteran Cahul – ARF Ialoveni
| 3:2 |
19/05/2022/ FC Chișinău – liberă
| |
| Etapa 7 |
26/05/2022/ 18:30/ ARF Ialoveni – Cricova
| 2:1 |
26/05/2022/ 19:30/ APSM – CS Olimp-Veteran Cahul
| 2:3 |
26/05/2022/ 20:30/ FC Chișinău – Geotermal Chișinău
| 2:6 |
26/05/2022/ Dnestr Tiraspol – liberă
| |
| Etapa 8 |
| 13/10/2022/ 18:00/ APSM – Cricova | 3:2 |
| 13/10/2022/ 19:00/ FC Chișinău – CS Olimp-Veteran Cahul | 6:2 |
| 13/10/2022/ 20:00/ ARF Ialoveni – Dnestr Tiraspol | 2:8 |
| 13/10/2022/ 21:00/ Geotermal Chișinău – Bucuria | 13:5 |
| Etapa 9 |
| 20/10/2022/ 18:00/ Bucuria – ARF Ialoveni | 2:2 (1:2 bulit) |
| 20/10/2022/ 19:00/ Dnestr Tiraspol – APSM | 7:2 |
| 20/10/2022/ 20:00/ CS Olimp-Veteran Cahul – Geotermal Chișinău | 1:3 |
| 20/10/2022/ 21:00/ Cricova – FC Chișinău | 2:8 |
| Etapa 10 |
| 27/10/2022/ 18:00/ ARF Ialoveni – FC Chișinău | 3:9 |
| 27/10/2022/ 19:00/ Dnestr Tiraspol – Geotermal Chișinău | 1:5 |
| 27/10/2022/ 20:00/ Cricova – CS Olimp-Veteran Cahul | 3:5 |
| APSM – Bucuria | transferat |
| Etapa 11 |
| 03/11/2022/ 18:00/ Geotermal Chișinău – Cricova | 16:4 |
| 03/11/2022/ 19:00/ APSM – ARF Ialoveni | 5:2 |
| 03/11/2022/ 20:00/ Bucuria – CS Olimp-Veteran Cahul | 3:6 |
| 03/11/2022/ 21:00/ FC Chișinău – Dnestr Tiraspol | 6:4 |
| Etapa 12 |
| 07/11/2022/ 18:00/ FC Chișinău – APSM | 3:4 |
| 07/11/2022/ 19:00/ CS Olimp-Veteran Cahul – Dnestr Tiraspol | 1:2 |
| 07/11/2022/ 20:00/ Cricova – Bucuria | 2:4 |
| 07/11/2022/ 21:00/ Geotermal Chișinău – ARF Ialoveni | 5:8 |
| Etapa 13 |
| 10/11/2022/ 18:00/ APSM – Geotermal Chișinău | 2:7 |
| 10/11/2022/ 19:00/ Dnestr Tiraspol – Cricova | 13:1 |
| 10/11/2022/ 20:00/ ARF Ialoveni – CS Olimp-Veteran Cahul | 2:9 |
| 10/11/2022/ 21:00/ Bucuria – FC Chișinău | 6:7 |
| Etapa 14 |
| 17/11/2022/ 18:00/ Cricova – ARF Ialoveni | 4:1 |
| 17/11/2022/ 19:00/ CS Olimp-Veteran Cahul – APSM | 2:3 |
| 17/11/2022/ 20:00/ Dnestr Tiraspol – Bucuria | 6:4 |
| 17/11/2022/ 21:00/ Geotermal – FC Chișinău | 3:7 |
